WRAP has said it will need to cut around 25 staff because of a “significant” drop in income.
The charity said there had been successive reductions in Government funding since 2015 and that it had struggled to identify alternative revenue streams.
WRAP became a charity in December 2014 after Defra slashed its funding of £25.7m in 2013-14 by half.
Consultations with staff are underway to identify which jobs are to be lost.
Chief executive Marcus Gover said the organisation will undergo a redesign to focus its efforts “where we can make the biggest impact”. He indicated that WRAP would need greater support from its business partners.
“We have been able to achieve great results by combining our resources with others to achieve impact with less funding, and that approach will continue,” he said.
“But we have now reached a point where we also need to make significant costs savings.
“Sadly, we cannot achieve the scale of savings we need without losing staff. This has been a difficult decision and is always a last resort. I am determined that the process of redundancy will be as fair and as compassionate as possible.”